Lupul returned to the lineup Saturday after missing one game due to injury, but left after two periods. He has 22 goals and 44 points in 69 games this season.
"He is going to have surgery done on his knee," coach Randy Carlyle said. "It's a meniscus procedure and will be done arthroscopically. It will be three weeks to a month recovery."
The Maple Leafs, who begin a three-game road trip to end the regular season Tuesday at the Tampa Bay Lightning, are three points behind the Columbus Blue Jackets for the Eastern Conference's second wild-card spot in the Stanley Cup Playoffs. The Blue Jackets also hold a game in hand.
It is really special. I had a lot of friends and family here tonight, and for my first [NHL] game in here it was great. I played here as an elementary-school player in the city championships and this was my first time back. It was a lot of fun..
— Toronto native Brandon Pirri after scoring 2 goals for Panthers in win at Maple Leafs on Thursday