"Looking forward to a game on Friday! I am in …," Datsyuk wrote on Twitter.
Datsyuk hasn't played since Feb. 27 due to inflammation in his right knee. He's played in 39 games this season and has 15 goals and 33 points.
"I saw him out there battling after practice," Red Wings coach Mike Babcock said. "If it appears he's ready and feels confident, then I'm sure he is."
His return comes at an opportune time for the Red Wings, who have six games left in the regular season and hold the first wild-card spot in the Eastern Conference for the Stanley Cup Playoffs with 86 points.
Datsyuk said he would see how he felt after playing Friday but he hoped to play in all six games.
"I'm kind of fresh, he's kind of fresh and [Abdelkader] is kind of fresh, so it'll be a pretty interesting line," Helm said.
Helm (concussion) and Abdelkader (finger) each also recently returned from injury.
Looking forward to a game on Friday! I am in...— Pavel Datsyuk (@Datsyuk13) April 3, 2014