The NHL-leading and Atlantic Division-champion Bruins had won a franchise-record nine straight on the road and had earned at least a point in their previous 16 games. Boston led the Red Wings twice, but couldn't put them away.
Detroit's Tomas Tatar scored early in the second period to tie it 1-1.
Nyquist has scored in three straight games and has a point in 10 consecutive. Since Jan. 20, he has netted an NHL-best 23 goals.
KINGS 4, COYOTES 0
LOS ANGELES (AP) — Drew Doughty and Anze Kopitar scored power-play goals, Jonathan Quick made 17 saves in his sixth shutout of the season, and Los Angeles clinched a playoff spot with a victory over Phoenix.
Kopitar, Jeff Carter and rookie Tanner Pearson each had a goal and an assist for the surging Kings, who have all but locked up third place in the Pacific Division and a first-round post-season matchup with California rivals San Jose or Anaheim.
Quick's shutout was the 31st of his career, leaving him one shy of tying Rogie Vachon's franchise record. Quick's six shutouts are second-most in the NHL behind Boston's Tuukka Rask.
Thomas Greiss stopped 28 shots for the Coyotes, whose playoff hopes have been hurt by three straight losses.
The Coyotes hadn't been shut out since a 2-0 loss to Columbus on Jan. 2.
ISLANDERS 2, SENATORS 1
Bailey, playing in his 400th NHL game, scored a power-play goal in the first period, and assisted on Casey Cizikas' winning goal midway through the third. Ryan Strome had two assists, and rookie Anders Nilsson followed up Evgeni Nabokov's home victory against Florida on Tuesday by making 35 saves. The Islanders have won three in a row and five of six.
Milan Michalek's power-play tally 6:41 into the third period was the lone goal for the Senators, who had won three straight. Ottawa had earned at least one point in five straight games.
DUCKS 3, OILERS 2
With the Ducks trailing 2-0, Perry scored his 40th goal just 37 seconds after Jordan Eberle doubled Edmonton's lead at 2:51. Perry then tied it with 8:35 left. It is the second time Perry has reached 40 goals in a season.
Rookie goalie Frederik Anderson (19-5) stopped 30 shots for the Ducks, 5-0-1 in their last six games.
Philip Larsen scored his third of the season in the first period for Edmonton.
Anaheim improved to 27-7-4 at home.