The NHL-leading and Atlantic Division-champion Bruins had won a franchise-record nine straight on the road and had earned at least a point in their previous 16 games. Boston led the Red Wings twice, but couldn't put them away.
Detroit's Tomas Tatar scored early in the second period to tie it 1-1.
Nyquist has scored in three straight games and has a point in 10 consecutive. Since Jan. 20, he has netted an NHL-best 23 goals.
ISLANDERS 2, SENATORS 1
Bailey, playing in his 400th NHL game, scored a power-play goal in the first period, and assisted on Casey Cizikas' winning goal midway through the third. Ryan Strome had two assists, and rookie Anders Nilsson followed up Evgeni Nabokov's home victory against Florida on Tuesday by making 35 saves. The Islanders have won three in a row and five of six.
Milan Michalek's power-play tally 6:41 into the third period was the lone goal for the Senators, who had won three straight. Ottawa had earned at least one point in five straight games.