Sedin was honored in a pregame ceremony for playing his 1,000th NHL game four games earlier.
The center, who leads the Canucks with 46 points, including five assists in his past three games, got up slowly after getting checked along the boards. He didn’t put much weight on his left leg as he limped to the locker room and did not start the third period of the 4-2 win.
"I went to hit a guy and he came back off the boards and he fell on top of me, so we'll see how it is tomorrow," said Sedin, who was walking with a very slight limp after the game. "I'm not declaring anything. We'll see how it feels tomorrow and go from there."
Forward Daniel Sedin returned against the Sabres after missing nine games with a hamstring injury, and forward Ryan Kesler came back after missing four with a sprained knee. Forward Alexandre Burrows missed the game after injuring his left hand in a game Wednesday.