The Canadiens did not specify if the injury was related to Prust's shoulder, which has caused him trouble throughout the season. Prust missed a month earlier in the season and more time once the NHL reconvened following the 2014 Sochi Olympics.
Prust returned to the lineup March 12 and played four games before sitting out the Canadiens' 3-2 home loss to the Columbus Blue Jackets on Thursday.
A Grade 1 shoulder separation caused Prust to miss eight games late last season.
In 52 games with the Canadiens this season, Prust has six goals, 13 points and a team-high 121 penalty minutes.
It's cool when you think about how many great American players have played the game and the two players that were at that 18-game point streak and what they've done in their careers. It's pretty cool right now, but it was kind of overshadowed by the loss.
— Blackhawks forward Patrick Kane after breaking the record for longest point streak by an American-born player with a goal and an assist in a 3-2 overtime loss against the Kings