Letang, who has not played since a Jan. 29 stroke and resulting discovery of a small hole in his heart, has been taken off blood thinner medication. The defenceman has missed the past 14 games.
"He still has some other things to go through (before returning to game action)," Penguins coach Dan Bylsma said, "but we knew that this was the six-week mark (since the stroke diagnosis) and there was a chance. He's been working out, he's been skating and doing quite a bit on his own."
A Norris Trophy finalist as the league's top defenceman last season, Letang signed an eight-year, $58 million contract extension last summer. He has 10 goals and eight assists in 34 games this season.
Letang did not skate at all for more than four weeks after the stroke and was not skating vigorously until this past week.