Semin tied it at 2 on a power play with 8:12 left, and Tlusty scored with 6:17 to go.
Jeff Skinner had a first-period goal — his 26th — to help Carolina win its second in a row after losing seven of eight. Nathan Gerbe had an empty-net goal with a second left.
Cam Ward made 21 saves, making his second consecutive start after backstopping the Hurricanes to a 3-1 victory over the New York Rangers on Tuesday night.
Tyler Ennis scored on a penalty shot and Drew Stafford added a goal for Buffalo. Michal Neuvirth made a season-high 51 saves in his second start for the Sabres since being acquired in a trade with Washington on March 5.
It's pretty crazy, but believe me when I say we didn't draft these players with the mindset we had to because they had good hockey-playing dads. It just turned out that way. But we're certainly glad they're a part of our organization.
— Arizona Coyotes director of amateur scouting Tim Bernhardt regarding the coincidence that six of the organization's top prospects are sons of former NHL players