Semin tied it at 2 on a power play with 8:12 left, and Tlusty scored with 6:17 to go.
Jeff Skinner had a first-period goal — his 26th — to help Carolina win its second in a row after losing seven of eight. Nathan Gerbe had an empty-net goal with a second left.
Cam Ward made 21 saves, making his second consecutive start after backstopping the Hurricanes to a 3-1 victory over the New York Rangers on Tuesday night.
Tyler Ennis scored on a penalty shot and Drew Stafford added a goal for Buffalo. Michal Neuvirth made a season-high 51 saves in his second start for the Sabres since being acquired in a trade with Washington on March 5.
The groove of being behind a bench is going to be interesting at first, but thank God we have a few exhibition games to get rid of those cobwebs. Overall the excitement of it all and the freshness and coming back refreshed, all those things are going to be assets. If [the players] come ready to give their best effort in practice and games, good things are going to happen. I'm always looking for results. It's not always on the scoreboard. It's winning and building something.
— Bryan Trottier on making his return to coaching as an assistant with the Sabres