Zetterberg didn't play Sunday night and Ken Holland says the team's leading forward is day-to-day.
He was hurt during Friday night's game against Montreal.
The Red Wings did welcome back forward Johan Franzen against the Panthers after he missed 16 games with a concussion.
Pavel Datsyuk was out for a 10th straight game with a lower-body injury and Holland says the centre is day-to-day. Jimmy Howard missed a third game in a row with an injured left knee and Holland says the goaltender might play Tuesday night at Philadelphia.
Forward Joakim Andersson missed his sixth straight game with a lower-body injury. He is expected to return against the Flyers or Friday night against Washington.
I don't have a crystal ball. Predicting is a real complicated thing. If we stay healthy, have enough depth and get the good goaltending we think we're going to have, you can go all the way. But a lot of things have to happen. There's going to be a lot of teams that think the same thing. Everyone made deals. We're all are optimistic about where we'll end up.
— Rangers general manager Glen Sather after being asked if he's constructed a team that can win the Stanley Cup before their 4-1 win against the Predators on Monday