Zetterberg didn't play Sunday night and Ken Holland says the team's leading forward is day-to-day.
He was hurt during Friday night's game against Montreal.
The Red Wings did welcome back forward Johan Franzen against the Panthers after he missed 16 games with a concussion.
Pavel Datsyuk was out for a 10th straight game with a lower-body injury and Holland says the centre is day-to-day. Jimmy Howard missed a third game in a row with an injured left knee and Holland says the goaltender might play Tuesday night at Philadelphia.
Forward Joakim Andersson missed his sixth straight game with a lower-body injury. He is expected to return against the Flyers or Friday night against Washington.
It's a tribute to him, and everything he's done and deserved is coming to fruition tonight with his jersey in the rafters. He's going to be a first-ballot Hall of Famer. And I said today, if he's not, take my stuff out. If he doesn't deserve to be in there first ballot, no one does. Except for (Wayne) Gretzky, I guess.
— Hockey Hall of Fame member Brett Hull on former teammate Mike Modano, whose No. 9 was retired by the Dallas Stars on Saturday