Zetterberg didn't play Sunday night and Ken Holland says the team's leading forward is day-to-day.
He was hurt during Friday night's game against Montreal.
The Red Wings did welcome back forward Johan Franzen against the Panthers after he missed 16 games with a concussion.
Pavel Datsyuk was out for a 10th straight game with a lower-body injury and Holland says the centre is day-to-day. Jimmy Howard missed a third game in a row with an injured left knee and Holland says the goaltender might play Tuesday night at Philadelphia.
Forward Joakim Andersson missed his sixth straight game with a lower-body injury. He is expected to return against the Flyers or Friday night against Washington.
What we expected is what we got. Very mature young individual that's focused. He is on the right track. He's not only a great hockey individual, but he's a good person off the ice. He seemed to take a leadership role with this group right off the hop and ran away with it, and was vocal, was respectful, was everything it takes to be a Panther. His future looks bright.
— Florida Panthers director of player development Brian Skrudland on defenseman Aaron Ekblad's performance at development camp