Zetterberg didn't play Sunday night and Ken Holland says the team's leading forward is day-to-day.
He was hurt during Friday night's game against Montreal.
The Red Wings did welcome back forward Johan Franzen against the Panthers after he missed 16 games with a concussion.
Pavel Datsyuk was out for a 10th straight game with a lower-body injury and Holland says the centre is day-to-day. Jimmy Howard missed a third game in a row with an injured left knee and Holland says the goaltender might play Tuesday night at Philadelphia.
Forward Joakim Andersson missed his sixth straight game with a lower-body injury. He is expected to return against the Flyers or Friday night against Washington.
I got a chance to play a thousand games and that's pretty special to me. To get a thousand [points], it's a great accomplishment. I'm not going to hide my feelings, I'm proud of that. To do it on a win, do it on a goal, I think it makes it special.
— New York Rangers forward Martin St. Louis after scoring his 1000th NHL point on Friday