Yakupov appeared to sustain the injury with just over a minute remaining in the middle period when he was checked off the puck by Wild forward Matt Cooke. Yakupov hit the ice hard and slid into awkwardly into the boards near the Edmonton bench.
Minnesota scored on the ensuing rush, giving the Wild a 3-1 lead.
Yakupov, the first player taken in the 2012 NHL Draft, has nine goals and eight assists in 47 games this season but was held off the scoresheet through 40 minutes Thursday. He was a minus-1 on the night and his minus-31 rating for the season is the worst in the NHL.