The 36-year-old Handzus was sidelined by an upper-body injury earlier in the season. He has one goal and three assists in 13 games.
While Handzus is ready to return, forwards Andrew Shaw and Bryan Bickell have been ruled out for Friday night's game. Shaw (upper body) could return as soon as Sunday against Florida, while Bickell (lower body) is expected to begin skating again in the next week.
Rookie goaltender Antti Raanta got his third career start for Chicago and his first at home.
This team has been a real treat to say you've been the head coach of them. I'm extremely proud of this group ... after the disappointment of (the Game 6 loss) is digested, it's always a lot easier as a coach when your team has emptied its tank, and that team emptied its tank for me for three months.
— Senators coach Dave Cameron after getting eliminated in the first round by the Canadiens