The 36-year-old Handzus was sidelined by an upper-body injury earlier in the season. He has one goal and three assists in 13 games.
While Handzus is ready to return, forwards Andrew Shaw and Bryan Bickell have been ruled out for Friday night's game. Shaw (upper body) could return as soon as Sunday against Florida, while Bickell (lower body) is expected to begin skating again in the next week.
Rookie goaltender Antti Raanta got his third career start for Chicago and his first at home.
Obviously there's a lot of expectations around me but it's something I try not to focus on. I'm just trying to go out there, be myself on the ice every day, try to get better, be myself around the guys in the locker room. I think that's what's made me successful and the person that I am.
— Sabres forward Jack Eichel on transitioning from college hockey to the NHL