The 36-year-old Handzus was sidelined by an upper-body injury earlier in the season. He has one goal and three assists in 13 games.
While Handzus is ready to return, forwards Andrew Shaw and Bryan Bickell have been ruled out for Friday night's game. Shaw (upper body) could return as soon as Sunday against Florida, while Bickell (lower body) is expected to begin skating again in the next week.
Rookie goaltender Antti Raanta got his third career start for Chicago and his first at home.
I don't have a crystal ball. Predicting is a real complicated thing. If we stay healthy, have enough depth and get the good goaltending we think we're going to have, you can go all the way. But a lot of things have to happen. There's going to be a lot of teams that think the same thing. Everyone made deals. We're all are optimistic about where we'll end up.
— Rangers general manager Glen Sather after being asked if he's constructed a team that can win the Stanley Cup before their 4-1 win against the Predators on Monday