The 36-year-old Handzus was sidelined by an upper-body injury earlier in the season. He has one goal and three assists in 13 games.
While Handzus is ready to return, forwards Andrew Shaw and Bryan Bickell have been ruled out for Friday night's game. Shaw (upper body) could return as soon as Sunday against Florida, while Bickell (lower body) is expected to begin skating again in the next week.
Rookie goaltender Antti Raanta got his third career start for Chicago and his first at home.
This is a great day for me. This is something I've been thinking about for a long time. This is a great opportunity that the St. Louis Blues organization, (owner) Tom Stillman and Doug Armstrong are giving me and trusting me in doing...This is going to be a great challenge for me.
— Martin Brodeur, after announcing his retirement as an NHL player and becoming a senior adviser with the Blues on Thursday