The 36-year-old Handzus was sidelined by an upper-body injury earlier in the season. He has one goal and three assists in 13 games.
While Handzus is ready to return, forwards Andrew Shaw and Bryan Bickell have been ruled out for Friday night's game. Shaw (upper body) could return as soon as Sunday against Florida, while Bickell (lower body) is expected to begin skating again in the next week.
Rookie goaltender Antti Raanta got his third career start for Chicago and his first at home.
This is a big year for us in a lot of ways. You can see Garth and management really trying to find that solution to get us into the playoffs and consistently have that. The pressure is great. You have to enjoy it. It just means there's a great opportunity ahead of you.