Victor Hedman and Keith Aulie left the game in the second period and didn't return. Hedman has a lower-body injury; Aulie suffered a broken hand.
Coach Jon Cooper said Hedman is day-to-day, but that he does not expect him to be ready Saturday against the Winnipeg Jets.
Aulie took one shift after a penalty at 5:46 of the second period and will have surgery Friday on a fractured hand. He is out indefinitely.
"They're going to call us the Syracuse Lightning pretty soon," Cooper said, referring to his team's American Hockey League affiliate. "It's emotional and physically taxing. You're playing with unfamiliar guys all the time and it's tough to get synergy and chemistry going, but we just won a game without those guys in the lineup."