Bryzgalov stopped 12 of 13 shots Monday night in relief of Devan Dubnyk in the Oilers' 5-1 loss to the Chicago Blackhawks and played the final 34:08 of the game.
"It wasn't the best way for us to throw him into the fire," Oilers coach Dallas Eakins said. "I thought he went in and played very well."
Bryzgalov was signed earlier this month after the Philadelphia Flyers bought out his contract over the summer.
The 33-year-old, who has also played for the Anaheim Ducks and Phoenix Coyotes, has a career record of 208-149-45 in 426 appearances with a 2.55 goals-against average, .913 save percentage and 30 shutouts.
It's really exciting. I'm pretty sure that when I play my first game I'm going to be emotional. To be back on the ice playing a game, being in game situations, with all the routines and rituals I do before games and during the game, I feel like I'm going to be emotional. I'm going to be really happy.
— Montreal Canadiens forward Tim Bozon on playing for the first time since his life-threaning illness