The Red Wings' home slide reached eight games (0-6-2).
They have gone seven games without a win overall (0-5-2) for the first time since the last seven games of the 2002 regular season, according to STATS.
That team went on to hoist the Stanley Cup. This team, though, appears to have a lot of heavy lifting ahead of it to contend for a championship.
Detroit's Jimmy Howard made 23 saves.
The Predators have won two straight after losing four in a row.
Weber gave the Predators a 1-0 lead on a power-play goal with 4.8 seconds left in the second period.
The Red Wings failed to clear the puck out of their end and Weber took advantage. Weber kept the puck in Detroit's end along the boards, passed it to David Legwand, who set him up perfectly for a slap shot just inside the blue line in the middle of the ice.
Bourque gave Nashville a two-goal lead at 7:13 of the third period, scoring off a rebound that caromed off the boards behind Howard.
Detroit lost a key player early in the game.
Red Wings defenceman Danny DeKeyser injured his left shoulder after getting checked into the boards on his second shift and didn't return. DeKeyser entered the game with two goals and ranked among rookie leaders with seven assists.
NOTES: Former Red Wings defenceman Chris Chelios was honoured before the game for being inducted into the Hockey Hall of Fame. ... NHL and Red Wings executives announced before the game that the 2014 Winter Classic is sold out. The Red Wings and Toronto Maple Leafs are expected play in front of 107,000-plus people on New Year's Day at Michigan Stadium. In the same football stadium, Michigan and Michigan State set a hockey attendance mark of 104,173 in 2010.
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