Semin was injured Saturday during the Hurricanes' 4-2 loss to the St. Louis Blues on a hit by Blues defenseman Alex Pietrangelo. Semin returned to the ice briefly after the hit, but left the game for good in the second period.
The 29-year-old was out of the lineup Monday against the Boston Bruins.
Semin, who was second on the Hurricanes with 44 points last season, has three goals and six assists in 20 games this season.
If you want to prove people wrong, you've just got to go out and do it. Yeah, we blew 3-2 series leads the last two years, but no one is going remember that if we go out there on Saturday night and beat these guys and go play in the Stanley Cup Final. We need to get back to work and we'll start to do that tomorrow.
— Ducks forward Kyle Palmieri after loss to Blackhawks on Wednesday set up Game 7 on Saturday