Brad Richardson, Mike Santorelli and Zack Kassian also scored for the Canucks, who had lost all five regular season meetings between the teams the past two seasons and were swept by San Jose in the first round of the playoffs last spring.
Joe Thornton and Mike Brown scored for the Sharks, who lost their fourth straight game, but just the second in regulation all season.
Antti Niemi allowed four goals on 12 shots before being replaced early in the second period as the Canucks controlled the play for much of the first 40 minutes and weathered a strong push from San Jose in the third.
It's something that you don't really envision starting this way, but when you put the work in you don't feel like it's unwarranted. You definitely don't envision it unfolding this way, but you do think you can be successful at this level.
— Senators goalie Andrew Hammond, who defeated the Jets on Wednesday to improve to 6-0-1 since making his first NHL start on Feb. 18