Letang has been out since sustaining a lower-body injury Sept. 27.
"As we've seen in practice this week, [Wednesday and Thursday], Kris Letang has moved into situations and a pairing that we will most likely see him in the game [Friday] with," Penguins coach Dan Bylsma said.
The Penguins also sent forwards Chris Conner and Harry Zolnierczyk to the American Hockey League and recalled forward Jayson Megna. The 23-year-old will make his NHL debut Friday; at practice Thursday he skated at right wing on a line centered by Brandon Sutter, with Tanner Glass at left wing.
"He's got NHL speed," Bylsma said of Megna. "He's a fast skater, brings speed to the game with some skill and ability and some jam, and that's what he's done this year in Wilkes-Barre [AHL]. He's had that speed and he's been able to be effective with it.
"He's used it on the penalty kill and been effective offensively with that speed and skill, and that's something we're looking for from him. He's shown that in the first six games in Wilkes-Barre and now getting that opportunity with us."