Craig Adams also scored his second goal and Chris Kunitz converted a penalty shot to help the Penguins open 2-0 for the third straight season. Pittsburgh defenceman Matt Niskanen added two assists and forward Pascal Dupuis, playing in his 800th game, also had an assist.
Fleury has sparkled through two games, turning aside 47 of 48 shots. He earned his 250th career victory and 24th shutout with a 3-0 win Thursday against New Jersey.
Thomas Vanek spoiled Fleury's bid for another shutout at 15:06 of the third period.