Brenden Morrow added his first playoff goal in more than five years, Tomas Vokoun made 19 saves and the Penguins rode their superstar captain to their fourth straight victory.
Crosby beat Craig Anderson three times in the game's first 22 minutes, sending the goalie to the bench after stopping 18 of 21 shots.
Kyle Turris, Colin Greening and Jean-Gabriel Pageau scored for the Senators, but couldn't stop Ottawa from falling into a deep hole against the Eastern Conference's top seed. The Senators have never won a playoff series after dropping the first two games.
I feel that responsibility, I've felt it for the last two years. We core guys get a lot of minutes, we get a lot of opportunity out there. Our teammates, the organization and fans look to us to be the guys to put the puck in the net and to create momentum out there.
— Jordan Eberle on taking his game and the Edmonton Oilers to the next level