Brenden Morrow added his first playoff goal in more than five years, Tomas Vokoun made 19 saves and the Penguins rode their superstar captain to their fourth straight victory.
Crosby beat Craig Anderson three times in the game's first 22 minutes, sending the goalie to the bench after stopping 18 of 21 shots.
Kyle Turris, Colin Greening and Jean-Gabriel Pageau scored for the Senators, but couldn't stop Ottawa from falling into a deep hole against the Eastern Conference's top seed. The Senators have never won a playoff series after dropping the first two games.
It's really exciting. I'm pretty sure that when I play my first game I'm going to be emotional. To be back on the ice playing a game, being in game situations, with all the routines and rituals I do before games and during the game, I feel like I'm going to be emotional. I'm going to be really happy.
— Montreal Canadiens forward Tim Bozon on playing for the first time since his life-threaning illness