Brenden Morrow added his first playoff goal in more than five years, Tomas Vokoun made 19 saves and the Penguins rode their superstar captain to their fourth straight victory.
Crosby beat Craig Anderson three times in the game's first 22 minutes, sending the goalie to the bench after stopping 18 of 21 shots.
Kyle Turris, Colin Greening and Jean-Gabriel Pageau scored for the Senators, but couldn't stop Ottawa from falling into a deep hole against the Eastern Conference's top seed. The Senators have never won a playoff series after dropping the first two games.
He's, believe it or not, actually one of my favorite guys, and I've ended up trading him twice. I appreciate what he's done. He was one year away from being an unrestricted free agent, and I felt with this opportunity, that it was a chance that we were able to get somebody for him in Nick Bonino and Adam Clendening.
— Penguins GM Jim Rutherford on forward Brandon Sutter