Neal injured an ankle in the opening game of the first-round series. Orpik has been sidelined for five games because of an undisclosed injury.
The Penguins have done just fine without both players, winning two of the first three games of the series.
Neal, who didn't record a point in the one game he has played in these playoffs, took line rushes with Evgeni Malkin and Jarome Iginla during pregame warmups. Neal had 21 goals and 36 points in 40 regular-season games.
They said, 'You're going to love the city. It's smaller than Philadelphia, but you're going to love it. You're going to love the fans. Just watching the playoffs last year, the fans seemed louder there than they did anywhere. I'm really excited about that.
— Forward Scott Hartnell on his upcoming season with the Columbus Blue Jackets