Neal injured an ankle in the opening game of the first-round series. Orpik has been sidelined for five games because of an undisclosed injury.
The Penguins have done just fine without both players, winning two of the first three games of the series.
Neal, who didn't record a point in the one game he has played in these playoffs, took line rushes with Evgeni Malkin and Jarome Iginla during pregame warmups. Neal had 21 goals and 36 points in 40 regular-season games.
It was definitely emotional. I really appreciated the fans. It was a cool feeling and it felt special and the ovation there at the start and then you kind of feel funny out there standing by yourself. Thinking back, I was saying just a bit ago, you think back just trying to make the NHL and then you kind of reflect on all the years being able to play for a great organization here in Calgary and all the fun I've had so far in my career. I feel very fortunate and blessed.
— Boston forward Jarome Iginla on his return to Calgary, where he played for 16 seasons