The team said on its Twitter account that Nugent-Hopkins is flying to Cleveland to have his shoulder examined and that surgery is likely.
After an impressive rookie campaign, Nugent-Hopkins' numbers were slightly down this year with just four goals and 20 assists in 40 games. He had 18 goals and 34 assists in 64 games in his first season after being picked first overall by Edmonton.
His left shoulder has been a re-occuring problem for the centre. He missed 20 games last season because of it and then had to leave the Oilers' AHL affiliate last December to do some strengthening and conditioning on the shoulder before playing for Canada at the world junior championship.
The Oilers, who will miss the post-season for the seventh straight year, have five games remaining, including a game at Anaheim on Sunday night.