A bloodied Crosby skated off the ice with a towel covering his mouth after Brooks Orpik's slap shot from the point deflected off a stick and hit the NHL scoring leader just 1:28 into Saturday's game.
Crosby, who immediately fell to the ice and tossed his stick in the air, did not return in the first period. Early in the second, the Penguins announced that he would not be back in the game.
Crosby has a history of concussions that have kept him out for long periods during his stellar career.
After the Penguins' 2-0 win over the New York Islanders, coach Dan Bylsma revealed that Crosby lost some teeth and would require oral surgery. He added that the team would continue to monitor their captain's situation.
Pittsburgh earned its 15th straight victory, which is two shy of the NHL record set by Mario Lemieux and the 1992-93 Penguins.
With 15 goals and 56 points, Crosby held a 10-point lead over Tampa Bay's Steven Stamkos in the NHL scoring race.