Malkin is sidelined Friday night because of an upper body injury, while Letang is dealing with a lower body problem.
Malkin, who earlier in the week eyed the matchup with the Islanders as a possible return date, sat out for a seventh straight time. Letang missed his second game and is considered to be day to day.
However, the Penguins haven't missed a beat without them. Pittsburgh is the first NHL team to record at least a 10-game winning streak in three consecutive seasons, according to the Elias Sports Bureau.
Stay Connected
NHL.TV™
NHL GameCenter LIVE™ is now NHL.TV™.
Watch out-of-market games and replays with an all new redesigned media player, mobile and connected device apps.
Introducing the new official NHL App, available for iPhone, iPad and Android smartphones and tablets. A host of new features and improved functionality are available across all platforms, including a redesigned league-wide scoreboard, expanded news coverage, searchable video highlights, individual team experiences* and more. The new NHL App on your tablet also introduces new offerings such as 60fps video, Multitasking** and Picture-in-Picture.
*Available only for smartphones
** Available only for suported iPads