Nick Bonino and Saku Koivu also scored for Anaheim. Corey Perry and Ryan Getzlaf assisted on all three goals by Palmieri, who hadn't scored since netting back-to-back game-winners on Feb. 1-2 against Minnesota and Los Angeles.
Palmieri completed his outburst against Pekka Rinne 1:07 into the second period, during a power play after Nashville had too many men on the ice.
It was the sixth natural hat trick in club history and marked the third career multigoal game for the 22-year-old forward, selected by the Ducks in the first round of the 2009 draft.
It's cool when you think about how many great American players have played the game and the two players that were at that 18-game point streak and what they've done in their careers. It's pretty cool right now, but it was kind of overshadowed by the loss.
— Blackhawks forward Patrick Kane after breaking the record for longest point streak by an American-born player with a goal and an assist in a 3-2 overtime loss against the Kings