Myers began the comeback 2 minutes into the third period, tying the game at 2 by backhanding in a rebound after Khudobin stoned Jochen Hecht on a 2-on-1 break.
The goals completed a stirring comeback for Buffalo, which trailed 2-1 going into the third. Entering the game, Boston (8-2-2) had outscored its opponents 15-5 this season in the final period.
The Bruins' only other loss in regulation this year came at home against Buffalo on Jan. 31.
Dougie Hamilton scored his first NHL goal and added an assist for Boston, which failed to earn a point for only the second time in 12 games. Rich Peverley also scored for the Bruins. Khudobin stopped 22 shots.
DEVILS 5, FLYERS 3
NEWARK, N.J. — David Clarkson scored on a deflection at 10:43 of the third period and New Jersey rallied from a two-goal deficit to defeat Philadelphia.
Travis Zajac, Alexei Ponikarovsky and Patrik Elias scored the Devils' other goals with Ilya Kovalchuk getting the primary assist on each. Martin Brodeur made 25 saves and had an assist, while Steve Bernier iced the game with an empty-net goal.
Clarkson's team-high 10th goal came on a deflection of a point shot by Adam Larsson. Elias assisted on the last two goals.
PENGUINS 3, JETS 1
WINNIPEG, Manitoba (AP) — Craig Adams scored his first two goals of the season to lift Pittsburgh to its seventh road win of the season.
Winnipeg has lost three straight at home and hosts Boston on Sunday.
DUCKS 5, RED WINGS 2
DETROIT (AP) — Andrew Cogliano scored two of Anaheim's three goals in the third period, sending surging Anaheim to its third straight win and seventh in eight games.
Viktor Fasth made 26 saves to become the first goalie in seven years to win his first seven career starts.
Cogliano snapped a 2-all tie 1:02 into the third and Bobby Ryan connected 48 seconds later. Cogliano capped the outburst with his fourth of the season at 18:11.