The Canucks said Bieksa, who underwent a CAT scan, is expected to miss 2-4 weeks, though there's no timetable for his return.
"He is out indefinitely," coach Alain Vigneault said before Thursday's game at Nashville. "We are going to bring the results back to our doctors in Vancouver and make an assessment from there."
Bieksa, who blocked a shot with his right foot in the first period of Wednesday's 4-1 win at Minnesota but played the rest of the game, was optimistic about a late-season return.
"Hopefully, I'll be back a month before playoffs and get ready for that," he told the team's website.
It's the seventh time in the last month a Canucks defenseman has gone down -- and the fourth time in the last five games. The Canucks already are without Keith Ballard, Dan Hamhuis, Alex Edler, Andrew Alberts and Lee Sweatt from their blue line due to a variety of injuries.
"Those are the challenges you're faced with and that's the one that's in front of us now," Vigneault said. "Our guys are going to have to pick up the slack and our kids are going to get an opportunity and our forwards are going to have to help them out and our goaltender is going to have to stop the puck."
The Canucks have lost 195 man-games to injury this season, 120 of them to defenseman.
Vancouver recalled defenseman Evan Oberg from its AHL farm team, the Manitoba Moose, Oberg, who turned 22 on Wednesday, has 6 goals and 16 points in 34 games this season. He played a pair of games for the Canucks last season.
Oberg is the 13th defenseman and 37th player to suit up for the Canucks this season. The franchise record of 42 players was set during the 1990-91 season.