Grabovski sustained a fractured wrist during the first period and is expected to be out of the lineup for six weeks. Primeau suffered a knee injury during the third period and will be out of the lineup from two-to-four weeks.
Grabovski has appeared in all 42 games this season and is tied for fifth in team scoring with 25 points. He did not miss a game due to injury last season.
Primeau has two goals and three assists and a plus-1 rating in 35 games this season.
The Maple Leafs will host the Florida Panthers at Air Canada Centre Tuesday at 7 p.m.
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