Malkin has four goals and 13 assists during an eight-game point streak.
Thomas also gave up four goals in the Panthers' last game, a 5-3 loss to the New York Rangers on Wednesday. Florida has lost four of its last five games.
The goalie change didn't slow down the Penguins. Jokinen took a pass from Malkin in the slot and rifled it over the glove of Clemmensen at 6:10 to make it 5-1.
Trailing 3-0, the Panthers got on the board on Upshall's power-play goal in the second. Upshall brought the puck in from the left side and beat Zatkoff with a backhander at 17:53.
The Penguins got it right back when Neal scored just 29 seconds later. Neal's wrist shot from low in the right circle whistled past Thomas to make it 4-1. Neal has 13 points in his last seven games.
The Penguins stretched their lead to 3-0 on Malkin's goal in the second. Malkin brought the puck through the Panthers zone and beat Thomas on the left side with a backhand shot at 7:23.
The Penguins scored two goals in 32 seconds in the first period.
During a power play, Neal passed from the left side to Kunitz in the slot. Thomas fell down and Kunitz found the open net at 10:45 to make it 1-0. It was the third goal in two games for Kunitz.
Jayson Megna shot from the slot and Vitale slid the rebound across the goal line at 11:17 for a 2-0 lead.
NOTES: Earlier this season, Zatkoff made his first career start for Pittsburgh in Florida's home-opener, a 6-3 loss on Oct. 11. . Penguins goalie Tomas Vokoun, on injured reserve since Sept. 30 following surgery for a blood clot, spoke with reporters between periods and said he still hopes to eventually resume his career. . Bergenheim played in his 400th NHL game. . Florida C Jesse Winchester returned after missing three games with a lower body injury.
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