The Avalanche are 4-0 under new coach Patrick Roy, their best mark since the franchise relocated from Quebec to Colorado for the 1995-96 season.
Giguere, making his first start of the season, made several sparkling saves. His best came midway through the second period when he stoned Patrice Bergeron on a 2-on-1 rush.
Andre Benoit and Duchene assisted on O'Reilly's goal.
Tuukka Rask stopped 28 shots for Boston and has allowed only three goals in three games. Boston was blanked for the first time in 72 games.
DUCKS 6, RANGERS 0
Teemu Selanne and Mathieu Perreault assisted on both goals by linemate Silfverberg, who had the second two-goal game of his career. He has scored four goals in his first four games with the team. Dustin Penner and Daniel Winnik each added a goal and an assist.
New York has been outscored 20-6 to start their first season under new coach Alain Vigneault. The Rangers lost 9-2 at San Jose on Tuesday.
The Ducks outshot the Rangers 37-34 for their third win in a row in the teams' first meeting in nearly two years.
Playing without injured All-Star forward Rick Nash, the Rangers fell to 1-3 on their nine-game trip, the longest to open a season in franchise history.
New York's Henrik Lundqvist, a finalist for the Vezina Trophy last season, stopped 31 shots in losing for the third time in four games.
HURRICANES 3, CAPITALS 2
Jason Chimera and Alex Ovechkin had goals for the Capitals, who won four of five from Carolina last season. Ovechkin has seven points (five goals, two assists), the most he has had after four games since 2010.
The Capitals went 0 for 5 with the extra man after converting six of 12 power-play opportunities during their first three games.
BLUE JACKETS 4, SABRES 1
BUFFALO, N.Y. (AP) — Marian Gaborik had a goal and two assists, and Columbus kept Buffalo winless.
COYOTES 4, RED WINGS 2
DETROIT (AP) — Michael Stone's goal with 4:47 left broke a tie and lifted Phoenix over Detroit.
Joakim Andersson and Jonathan Ericsson scored for Detroit, and Jimmy Howard stopped 35 shots. Andersson and Ericsson scored 53 seconds apart early in the second period to give the Red Wings a 2-1 lead.
Stone fired a slap shot from the right point that went through teammate Martin Hanzal's and caromed in off the far goal post. It came 2 seconds after a Coyotes' power play ended.
Vermette added an empty-net goal in the last minute.
LIGHTNING 7, PANTHERS 2
Stamkos, second in the NHL with 29 goals during the abbreviated 2012-13 season, stopped a five-game scoring drought, dating to last season. The centre completed his sixth NHL hat trick with a one-timer from the top of the left circle during a power play at 12:25 of the third.
WILD 2, JETS 1
Bryan Little's goal in the final minute of the first period during a 5-on-3 power play tied the game for the Jets, who were outplayed from start to finish in their first road game of the season.
After scoring five goals in each of their first two games, the Jets have only three goals and 32 shots over their last two contests.
MAPLE LEAFS 4, PREDATORS 0
Bernier extended his domination of Nashville, improving his record against the Predators to 8-1. He stopped eight shots in the first period, 17 in the second and 11 in the third for his first shutout this season and the seventh of his NHL career.
After a scoreless opening period, Kessel scored the first goal at 13:41 of the second.
SHARKS 4, CANUCKS 1
CANADIENS 4, OILERS 1
Ryan Smyth scored for the Oilers (1-3), who will start a six-game road trip.
Edmonton's best early opportunity came 11 minutes in when defenceman Justin Schultz pinched in from the point and had a point-blank shot on net, but hit Montreal goalie Peter Budaj in the face, ripping off his mask.
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