Bertuzzi, who has been nursing a groin injury, will miss up to a month with mononucleosis.
"Bert's got mono," Red wings coach Mike Babcock said Saturday. "When we talked to him [Friday], we knew something was wrong. He's got mono, so he's going to [miss] a chunk of time."
Asked if it will be weeks, Babcock replied: "Oh yeah, for sure. Probably."
Bertuzzi, who turns 38 on Feb. 2, could go on injured reserve, which would clear a spot for injured Darren Helm (back) to return.
Bertuzzi has 751 points in 1,093 career games.
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