His fifth contest will introduce him to another one -- the Battle of Alberta.
While Nugent-Hopkins, the first pick of the 2011 Entry Draft, hasn't experienced the clash first hand, he's more than familiar with it, having played his junior hockey in Red Deer, which is situated almost exactly between the two Alberta cities.
"You always watch these games and they're always intense," Nugent-Hopkins said. "There's obviously a big rivalry between the two teams. It should be really fun."
If Nugent-Hopkins is unsure of what to expect, he can ask teammate Jordan Eberle.
Eberle was introduced to the Battle of Alberta in his first National Hockey League game last season, scoring his first NHL goal -- this highlight-reel beauty -- against Flames goaltender Miikka Kiprusoff.
"It was a lot of energy in Rexall and probably my fondest memory in the NHL," Eberle said. "Everyone remembers their first goal and that was special to me."
Flames forward Curtis Glencross is hoping to make Nugent-Hopkins' Battle of Alberta debut a little less memorable.
"He's been walking around untouched for a few games," Glencross said. "It's not our style of game. There's a good chance our line will be up against him tonight, so we'll have to get some bangs in early and see how he likes hitting."
The contest could mark the season debuts for players on both sides.
Oilers defenseman Ryan Whitney, recovering from an ankle injury, is expected to be in tonight's lineup, as is Flames center Brendan Morrison, who has been sidelined recovering from surgery to repair a torn knee ligament.
Morrison, who will decide following pre-game warm-ups if he can go, said the Battle of Alberta would be a great way to test his knee.
"It will be a good test," he said. "It's not going to be a pond hockey game out there, I don't think. I'm looking forward to it if I do play. It's going to be a game-time decision here, so I'll prepare like I'm playing and I look forward to it."
If Morrison can't go, expect Roman Horak to take his place.
It was kind of touching. I didn't know really what to expect. I'm very appreciative and thankful for the people that supported me in my time here ... as I said, we'll move back to the area at some point in our life.
— Toronto coach Randy Carlyle on the video tribute and ovation he received in his first game back in Anaheim, a 3-1 win for the Maple Leafs