Clowe was hit hard by Panthers forward Quinton Howden late in the second period and needed help leaving the ice. He did not return to the game.
Devils general manager Lou Lamoriello told The Record that Clowe is fine but is day-to-day. He did not accompany the Devils on their trip to Buffalo.
The Devils did not hold a morning skate Tuesday, so the makeup of their lineup won't be known until game time. One player who could take his spot is forward Tim Sestito, who was one of two players to take the ice Tuesday morning. Sestito hasn't played since being elbowed in the head by Minnesota Wild defenseman Nate Prosser on March 20.
"I haven't had any setbacks," Sestito told The Record. "I've felt fine. I just needed some time practice and skates and stuff, but since then I feel like I'm up to speed."
The Devils also recalled forward Mike Sislo from Albany of the American Hockey League and he is an option as well.
The Sabres will keep the same lineup from their most recent game, with the exception being Ville Leino drawing into the lineup in place of Nicolas Deslauriers. Coach Ted Nolan said Deslauriers won't play after being with his wife for the birth of the couple's daughter Monday.
"He didn’t have too much sleep the last day or so," Nolan told the Buffalo News. "He'll spend some time with his newborn and his wife, and he'll be back ready to go [Wednesday]."
Here are the lineups the Devils and Sabres could go with Tuesday:
Scratched: Mike Sislo
Scratched: Nicolas Deslauriers
Injured: Kevin Porter (lower body), Chris Stewart (ankle), Alexander Sulzer (upper body), Michal Neuvirth (lower body), Jhonas Enroth (lower body), Torrey Mitchell (undisclosed), Tyler Myers (midsection), Zenon Konopka (back)