Anderson had not started since Mar. 10, when he sustained an upper-body injury in a 4-3 overtime loss to the Nashville Predators.
The Senators, who host the Carolina Hurricanes on Monday, began a five-game homestand Friday and are in the midst of a stretch of six games in nine days.
Calgary (31-36-7), which beat Ottawa 4-1 at home on March 5, is in 13th place in the Western Conference with 69 points. The Flames have won six of their past nine, including a 4-3 victory Friday against the New York Rangers.
"The Flames are playing very well and they're always very hard as a group," Senators coach Paul MacLean said. "They're playing a very good team game and they're playing competitively, and that's what they did to us a month ago and we have to expect they're going to do that again today, so we have to make sure we have our work clothes on and that we're here to work."
Ottawa left wing Colin Greening will miss the game because of a lower-body injury. Defenseman Chris Phillips, who will be a game-time decision, has missed the Senators' past two games with an undisclosed injury.
Calgary is without defenseman Ladislav Smid, who sustained a lower-body injury Friday. Smid did not make the trip. The Flames recalled defenseman Chad Billins from Abbotsford of the American Hockey League on Saturday.
"I guess that he was doing better [Sunday] morning, talking to our medical guys, so I don't have a time frame yet for his return, but apparently this morning he was doing better," Calgary coach Bob Hartley said.
Forward Bryce Van Brabant will watch the game from the Canadian Tire Centre press box with Flames special assistant to the general manager Craig Conroy. Van Brabant signed with Calgary as a free agent Saturday after completing his third ECAC season at Quinnipiac, where he had 15 goals and seven assists for 22 points in 40 games.
He will make his NHL debut Tuesday against the Toronto Maple Leafs.
"It's basically the same thing as we do with every young player coming in," Hartley said. "Tonight he's going to watch the game with Craig Conroy. He's going to kind of explain from the press box parts of our system, [Monday] we're going to sit, we're going to do video, we're going to put him in practice, after practice on the ice we'll kind of guide him through again, and yes, he'll play against the Leafs."
Here are the expected lineups for the Flames and Senators: