Bobrovsky, the reigning Vezina Trophy winner, is feeling the lingering effects of the flu that forced him out of the game Tuesday after one period against the Detroit Red Wings.
Curtis McElhinney relieved Bobrovsky, who allowed one goal on 10 shots against Detroit. McElhinney stopped 22 of 23 Red Wings shots in the 4-2 win and will start against the Penguins. Mike McKenna, recalled from the Springfield Falcons of the American Hockey League, will be the backup.
Bobrovsky did not practice Thursday or participate in the optional skate Friday morning but he did get on the ice to work with goalie coach Ian Clark about 15 minutes after most players left.
"I feel a little bit better," Bobrovsky said. "I feel weakness. My throat's sore. I have low energy. We decided between the doctors and coaches not to play this game."
Bobrovsky was not feeling well before the Detroit game but convinced coach Todd Richards he could play, only to get sick during the first intermission.
A decision on whether Bobrovsky plays Saturday at the Carolina Hurricanes will be made that day.
Richards said it was an easy choice to turn to McElhinney against the Penguins.
McElhinney is 9-9-1 in 25 games this season with a 2.75 goals-against average and a .909 save percentage. He has played four times against Pittsburgh this season with three starts, posting an 0-3-0 record, 2.44 goals-against average and .900 save percentage.
His last start was a 3-2 loss to the Ottawa Senators on Jan. 28.
"Curtis has done an outstanding job for us all season long," left wing Nick Foligno said. "We have full confidence in our goaltending. It comes down to what we do in front of them that matters most."
The Blue Jackets (37-29-6), who have lost all four games against the Penguins (46-22-5) this season, will make no other changes from the Detroit game.
The Penguins held an optional skate Friday with few players participating, but there could be at least one more alteration to the lineup because center Marcel Goc suffered a lower-body injury late in the second period Thursday and did not return.
With Evgeni Malkin (foot) out, the Penguins could be down to two true centers.
Here are the projected lineups for the Penguins and Blue Jackets:
Scratched: Deryk Engelland
Injured: Evgeni Malkin (foot), Kris Letang (stroke), Paul Martin (broken hand), Joe Vitale (upper body), Chris Conner (broken foot), Pascal Dupuis (ACL), Tomas Vokoun (pelvis), Marcel Goc (lower body)