The Bruins are perfect since a 4-2 loss to the Washington Capitals on March 1 and can clinch a Stanley Cup Playoff berth with a win against the Avalanche. They also can clinch by picking up one point against the Avalanche if the New York Rangers lose in regulation Friday to the Columbus Blue Jackets.
Boston has a comfortable lead in the Atlantic Division, tops the Eastern Conference with 99 points and is two points behind the St. Louis Blues for first in the NHL.
"They've been real hot lately," Avalanche center Matt Duchene said of the Bruins, "so we want to put an end to their streak. You want to finish as high as possible, whether that's second or first [in the division]. St. Louis is pretty far ahead, so it'll be tough to catch them.
"We have tremendous respect for [the Bruins] because they're a top team in the League, but we don't give them too much respect. We believe this should be a good game [Friday] and one that we can win. We want to crank it up. We have a little extra motivation just because of the way the last two games on the road went."
Center Paul Stastny will play after missing five of the past six games with a back injury, but center John Mitchell will miss his second game in a row after hurting his back in Montreal. Defenseman Tyson Barrie will play right wing on the Avalanche's third line with left wing Cody McLeod and center Maxime Talbot.
The Bruins are 9-0-3 in their past 12 road games and haven't lost in regulation on the road since a 4-2 loss to the Los Angeles Kings on Jan. 9.
Bruins defenseman Johnny Boychuk, who has missed two games with a foot injury, will be a game-time decision against the Avalanche. He took part in an optional skate Thursday, participated in the morning skate Friday and will test his foot in the warmup.
Goalie Chad Johnson is expected to start. He's won four consecutive games and has allowed two goals or fewer eight times while posting a 9-0-1 record in his past 10 decisions.
Here are the projected lineups for the Avalanche and Bruins: