In his first start since Nov. 3, Anderson stopped 26 of 31 shots Tuesday in a 5-0 loss to the Philadelphia Flyers. He missed three games because of a sore neck, the result of a goalmouth collision with Dallas Stars rookie Valeri Nichushkin.
Robin Lehner led Ottawa to three straight wins while Anderson was sidelined. Lehner was named the NHL's First Star of the Week on Monday after posting a 1.33 goals-against average and .958 save percentage in wins against the Columbus Blue Jackets, Montreal Canadiens and Florida Panthers.
After making the point that "Craig's the No. 1 goalie," Senators coach Paul MacLean joked about how he arrived at the decision to come back with Anderson against Boston.
"It came up heads?" MacLean said after Ottawa's morning skate.
The Senators committed 20 turnovers in the loss to Philadelphia, which ended a five-game point streak (3-0-2).
"This game is a team game and one person's just a piece of that puzzle," Anderson said. "This isn't football. It's not a sport where it's the quarterback and he's the guy. This is a collective effort and it's not golf, it's not tennis. You need your teammates to help you succeed and when teams are winning everybody seems to be pulling on that rope.
"When things aren't going the way you want it just seems like that maybe three or four guys are going, three or four aren't and it's just kind one of those things where it's just not everybody's on the same page."
The Bruins did not skate Friday in Ottawa in the wake of their 3-2 overtime win against the Columbus Blue Jackets on Thursday.
These are the likely lineups for the Bruins and Senators:
Scratched: Jordan Caron
Injured: Adam McQuaid (lower body)
Injured: Erik Condra (right leg muscle strain)