The Bruins took a 3-1 series lead into the potential closeout game.
Seidenberg was injured on his first shift of Game 7 of the Eastern Conference Quarterfinals against the Toronto Maple Leafs on May 13. He was unable to continue after he tried to take a second shift.
Seidenberg, who started skating with the team about a week ago, ranked second on the Bruins in average minutes per game and led the team in blocked shots during the regular season. In his first seven playoff games, he recorded one assist and an even plus/minus rating.
Rookie Dougie Hamilton, who has three assists in seven postseason games, was scratched to make room for Seidenberg.