It will be his second straight start; he stopped 38 of 40 shots Saturday as the Penguins beat the Boston Bruins 3-2 to clinch the top seed in the Eastern Conference.
Marc-Andre Fleury did not make the trip to Ottawa with the team, as his wife is about to have a baby.
Eric Hartzell, signed April 14 after leading Quinnipiac University to the Frozen Four championship game, will serve as the backup.
The Penguins also will not have defenseman Kris Letang or rookie forward Beau Bennett in the lineup. Letang did not practice Sunday and did not travel with the team due to a case of food poisoning. Bennett is day-to-day with an upper-body injury.
Here are the projected lineups for the Penguins and Senators :