Alfredsson, 40, has a minus-2 rating with one shot on goal in one preseason game.
Forward Johan Franzen also will not play. The team's website said he skated Thursday morning with the first group at Joe Louis Arena but is experiencing a painful hip flexor. Mikael Samuelsson will replace Franzen in the lineup.
"He aggravated an injury there," Blackhawks coach Joel Quenneville told reporters in Chicago after his team's morning skate in preparation for a preseason game Thursday against the Pittsburgh Penguins. "We're going to keep him off. I wouldn't expect him in the next four games here in the next five nights. We'll see how he progresses after that."
However, Quenneville said he expects Hossa to be ready for the regular-season opener, Oct. 1 against the Washington Capitals (8 p.m. ET, NBCSN).
"Whether we're talking seriousness of it or not, we feel he'll be back and he'll be fine," Quenneville said.
Chicago Blackhawks players and fans get to celebrate for another day as the Coors Light NHL Stadium Series comes to their home. Our hosts Steve Mears and EJ Hradek will get you ready Thursday afternoon for that announcement live from Soldier Field. Then, at 5 p.m. ET, NHL Live will be joined by Blackhawks and Pittsburgh Penguins guests from the storied football stadium to talk about the outdoor game and the upcoming season.
With the reality of realignment on the horizon as we get closer to #NHLFaceOff, it's Central and Metropolitan Division day on NHL Live. We'll break down some new faces, look at coaches on the hot seat and get EJ's predictions for these two new divisions.
Remember to submit your #AskEJ questions all season long to @NHLNetwork or @EJHradek_NHL, and join the conversation on Twitter as we ask your opinion on some hot topics around the NHL.
The Carolina Hurricanes on Wednesday trimmed their training camp roster by 12 players, sending 11 to the Charlotte Checkers, their American Hockey League affiliate, and returning another to his junior team.
It's an incredible feeling just to see it go in and see the Joe go pretty crazy. Ever since the introduction there, I was kind of feeling the nerves, and to put that one home, I started to feel comfortable and I thought my play started to pick up.
— Nineteen-year-old Red Wings forward Dylan Larkin after scoring a goal in his NHL debut
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