Each team enters with a 7-1-0 record. The Avalanche are one point behind the San Jose Sharks at the top of the Western Conference standings, while the Penguins stand alone atop the Eastern Conference.
Forward Matt Duchene, who leads Colorado with nine points (three goals, six assists), said the game will be about more than Crosby vs. MacKinnon.
"This [Pittsburgh] has been one of the premier teams in the NHL," Duchene said. "They get a lot of media attention and a lot of attention from fans. We're a team that hasn't been good for the past few years and has previously been forgotten about until recently. We're starting to hopefully bring the glory days back to the Avalanche and we want to be one of those teams.
"I think if we can come out and have a win, everyone's going to sit back and say, 'Whoa, the Avs are for real.'"