Karlsson scored twice in the final 8:48 and Anderson stopped 33 shots in the Senators' 2-1 victory against the Florida Panthers at the BankAtlantic Center.
"It was a tight game," Karlsson said. "We stuck in there and finally got a crap goal, if I can say it like that. Both goalies played really well. We put as many pucks to the net as we could and finally one snuck in and that was all we needed today."
Anderson, a backup in Florida for two seasons before signing with Colorado in the summer of 2009, came within 4:13 of his second shutout since being acquired by Ottawa on Feb. 18. Anderson, who has started every game since coming to the Senators, has allowed one goal or fewer in seven of his nine starts.
"A win's a win, we'll take the two points," said Anderson, 3-0-1 in five career games against his former team. "A shutout is a great accolade to have, but the more important thing is the team got the win and everyone's happy in the room."
Anderson outdueled his former goalie partner, Tomas Vokoun, who stopped 37 shots.
"It's great to get two points and get the win and coming into an old barn, I used to play on the other side, that means a little bit more," Anderson said. "There's not a whole lot of guys on that team that I've played with, but I do still know some on that team. It's good to shut those guys down and come out of here with a 'W."'
Karlsson opened the scoring at 11:12 of the third with his 10th goal of the season. He took a loose puck along the boards, skated in on Vokoun and fired a quick shot from a sharp angle. The puck trickled in after getting through between Vokoun's left arm and his body.
"It's nice to get 10 goals," Karlsson said. "It's a big accomplishment for me. I just tried to get it far post and saw it roll in from behind the net."
Karlsson scored again with 5:10 left by firing home a rebound after Vokoun stopped Sergei Gonchar's slap shot from the point.
Clay Wilson spoiled Anderson's shutout with his second goal in the last two games. He swept the puck past Anderson after Niclas Bergfors' pass toward the net was deflected.
Wilson, who has spent most of the season in the AHL, also scored Tuesday night in Florida's 3-2 victory over Chicago.
"(Tuesday) night it was just kind of get the puck to the net and tonight just skating to the net, nothing fancy," Wilson said. "Just kind of got a couple of bounces going my way."
Early in the third period, Ottawa killed a 5-minute Florida power play after Francis Lessard was given a major and game misconduct when he appeared to leave his feet and checked Scott Timmins in the head area. Timmons didn't return to the game after the hit and will be re-evaluated Friday for a possible concussion
"You get a chance like that, five minutes, if you don't capitalize on that, it gives them momentum and that's kind of what happened," Wilson said. "They came out and got the first two and it was just a little too little too late."
Ottawa has won all three meetings this season. The Senators won 5-3 on Oct. 28 and took the second 5-1 on Feb. 23 in Anderson's second game with the team.
"It was a bad hockey game, I think, both ways," Panthers coach Pete DeBoer said. "The goalies were the two bright spots on the ice. We looked like we could play for weeks and not score a goal at some points there."
Material from wire services was used in this report
|Power Play %||16.8%||16.3%|
|% on Road||18.2%||15.9%|
|% at Home||15.5%||16.5%|
|Dmitry Kulikov Interference against Erik Condra|
|Dmitry Kulikov Hi-sticking against Bobby Butler|
|Zack Smith Interference against Dmitry Kulikov|
|Stephen Weiss Hooking against Ryan Shannon|
|Erik Karlsson Holding against David Booth|
|Jason Spezza Roughing against Mike Weaver|
|Francis Lessard Charging (maj) against Scott Timmins|
|Francis Lessard Game misconduct|
|Mike Santorelli Hooking against Zack Smith|