Weiss scored his second goal of the game 43 seconds into overtime as the Florida Panthers earned a 4-3 victory against the Avs at the BankAtlantic Center.
"It was a big goal for sure, just for the club and personally," Weiss said. "It's been a bit of a struggle, so it feels good to get it. Scored some big ones. Don't really want to say that's the biggest one of all time, but certainly to this point of the season it's a big one."
Bill Thomas and David Booth also had goals for Florida, which has won two straight following a three-game losing streak. Tomas Vokoun made 22 saves.
John-Michael Liles, Daniel Winnik and Matt Duchene scored for the Avalanche, who have lost four in a row. Colorado's Kevin Shattenkirk had his point streak snapped at nine games, leaving him one short of the NHL record for a rookie defenseman.
Craig Anderson, who served as Vokoun's backup for four seasons before signing with Colorado last offseason, made 21 saves.
"It was kind of back and forth, and whoever made the most mistakes was going to lose," Anderson said. "Unfortunately we didn't play the way we wanted to. We turned over the puck at some key times and that cost us the game. That's it in a nutshell."
Weiss gave Florida the victory with a spectacular goal. Anderson stopped Booth's shot from the wing, and Weiss was hooked after he got the rebound. He scored the winner while falling to the ice.
"A big second effort," Panthers coach Peter DeBoer said. "That second-effort goal is what he's all about."
The Panthers celebrated their 1996 Stanley Cup Final appearance against the Avalanche, who beat them for the championship that season. The captains from those teams -- Florida's Brian Skrudland and Colorado's Joe Sakic - dropped the ceremonial first puck.
Duchene gave Colorado a 3-2 lead at 1:59 of the third period when he skated around defenseman Dennis Wideman and beat Vokoun with a low shot between the legs. It was the sixth time Duchene has scored in the last seven games.
"I'm not doing much different," Duchene said. "Things are coming a little easier. The big thing is I'm shooting the puck more on goal, and you get rewarded."
Booth tied it at 4:11 when he skated across the line, deked forward David Jones, and fired a wrist shot that beat Anderson to the glove side.
Winnik's goal at 17:39 gave Colorado a 2-1 lead, but Weiss tied it 1:16 later off a nice feed from Steven Reinprecht. Weiss one-timed Reinprecht's pass from behind the net, beating Anderson on the short side.
"It was a huge comeback goal," DeBoer said. "We've been in that situation a bunch of times this year and haven't had a response. It was nice that both our big guys responded to goals against -- Weiss on that shift and then Booth in the third period. That's where you need all your best players."
Material from wire services and team media was used in this report.
1 - 0 FLA
1 - 1 Tie
2 - 1 COL
2 - 2 Tie
3 - 2 COL
3 - 3 Tie
4 - 3 FLA