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On Tuesday night, the Blue Jackets look to avoid a fifth consecutive defeat to the Blues when the teams meet at Nationwide Arena.
Looking for its third straight win since the All-Star break, Columbus (24-21-5) lost 7-3 to Dallas at home on Saturday. It was the Blue Jackets' worst defeat since losing 7-2 to Edmonton on Nov. 18.
"Just forget about it, put it behind you and move forward," said Columbus' Wade Dubielewicz, who allowed four goals in his Blue Jackets debut after replacing Steve Mason, who gave up three on eight shots.
Despite owning a 15-8-1 record at Nationwide, the Blue Jackets have struggled overall against the Blues, whose 45 points are the fewest in the Western Conference .
St. Louis (20-24-5) has outscored Columbus 30-13 in winning six of the last seven in the series. The Blues won 5-2 at home on Jan. 3 in the only meeting this season.
Poor defense has plagued the Blue Jackets against St. Louis, and also contributed to Saturday's loss.
The Stars led 3-0 in the first period before the Blue Jackets came within one early in the second. Dallas then scored twice in each of the final two periods to pull away.
"I thought our goaltending wasn't very good, but they aren't the total blame," Columbus coach Ken Hitchcock said. "We were really soft."
Despite struggling in his last game, Mason figures to be back in net Tuesday. The rookie, who is 19-11-2 with a league-leading 2.06 goals-against average, matched a season high in goals allowed in last month's loss to St. Louis.
Kristian Huselius had a goal and an assist for the Blue Jackets on Saturday. He has 10 points in his last seven contests overall and three goals and five assists in his last four versus St. Louis.
Fredrik Modin and Rick Nash each recorded an assist Saturday and combined for a goal and three assists last month versus the Blues.
Rookie T.J. Oshie had a goal in that contest for St. Louis and added one in the Blues' 4-3 shootout loss at Detroit on Monday. Fellow rookie Patrik Berglund also scored as St. Louis earned a point for the sixth time in seven games.
Oshie has a goal and two assists in his last two games, while Berglund is looking for a goal in his third straight contest.
Like Columbus over the weekend, St. Louis was plagued by poor goaltending in its most recent contest.
Chris Mason stopped 13 shots after replacing Manny Legace, who gave up three on eight shots in his first action since suffering a lower-body injury Jan. 19.
"I feel bad for Manny," Blues coach Andy Murray said, "because there's been a lot of nights, since I've been coaching the Blues, that he's been the best guy in the NHL.
Both Legace and Chris Mason have fared well against Columbus. Legace is 18-4-0 with a tie and a 2.21 GAA versus the Blue Jackets, while Chris Mason is 9-1-1 with a 1.79 GAA.
St. Louis snapped a four-game losing streak at Columbus with a 4-1 victory on April 6.