The Flyers (11-6-5) have lost 10 of their last 13 to the Leafs (7-9-6), including four of six in Toronto, and enter this contest after having their six-game run end with Friday afternoon's 3-2 overtime loss to Carolina.
Philadelphia's win streak may have been snapped, but the team earned a point for the ninth straight game (7-0-2).
The Flyers tied Friday's contest at 2 on Jeff Carter's goal late in the second period before the Hurricanes' Sergei Samsonov broke through against Martin Biron with 1:07 left in overtime.
"We had some great opportunities that we didn't capitalize on," Philadelphia coach John Stevens said. "We let (Carolina) hang around and because of that, they end up winning the hockey game."
Carter, who is among the league leaders with 16 goals, also had an assist and extended his point streak to five games. Simon Gagne, the Flyers' leader with 30 points, had a career-high nine-game point streak snapped.
Carter has scored goals in three of the last four meetings with the Maple Leafs, and Gagne has two goals and an assist in the past three matchups.
Biron lost for the first time in five starts, but he hasn't suffered a regulation loss in his last seven games, going 5-0-2. His largest ally in that run is the Flyers' penalty kill. Philadelphia has killed off 20 straight penalties and allowed opponents to go 2-for-53 in the past 10 contests.
Biron is 1-2-2 in his last five games against Toronto, but 3-0-3 in his past six starts at the Air Canada Centre.
Toronto allowed less than three goals for the first time in five games Thursday, but lost 2-1 in a shootout at Ottawa for its fifth straight defeat (0-3-2).
Vesa Toskala, who lost his fourth straight start, stopped 34 shots in regulation and overtime - one shy of his season high set Oct. 9 at Detroit - but couldn't stop the Senators' Jason Spezza and Daniel Alfredsson in the shootout.
Toskala has allowed one goal or fewer in two starts this season and lost both. He has gone 2-4-3 over his last nine starts after starting the season 5-2-2.
The Maple Leafs goalie has won all three meetings against Philadelphia.
Matt Stajan, Toronto's leader with 20 points, failed to record a point for just the third time in the last 16 games Thursday. He hasn't had a point in the last five games against Philadelphia and hasn't scored a goal in 14 career meetings.
Toronto agreed to a six-year deal with Brian Burke to take over as president and general manager on Saturday.
Burke spent the past three-plus seasons with Anaheim and helped lead the Ducks to a Stanley Cup title in 2007. He left Anaheim Nov. 12 after declining to sign a contract extension.
"I think it's way too premature to assume he's coming in with an axe," said Maple Leafs coach Ron Wilson, Burke's college roommate at Providence. "We haven't had any discussions about this team."
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