Calgary (35-21-9) has won four of its last five games at the Scottrade Center, outscoring St. Louis 19-9 in those meetings. The Flames have also won their last five matchups with the Blues (28-27-10) overall, and are 7-0-1 the last eight times the teams have faced each other.
The only Calgary loss in that span was a 3-2 shootout defeat at St. Louis on Jan. 30, 2006.
The Flames, who are 8-15-8 on the road and tied with Florida for the fewest wins away from home in the NHL, opened a three-game trip Saturday by snapping a seven-game road losing streak, defeating Edmonton 4-2.
"It's about us finding ways to win on the road," said Calgary coach Jim Playfair, whose club has earned its last two road victories against the Oilers. "That's the biggest thing. It is an area that we have a lot of improvement to make in. Coming out of this game with two points to start our road trip is important."
Despite the road woes, Calgary has put together a four-game winning streak for the first time since winning five in a row from Jan. 4-13, and is two games shy of its season-high six-game run from Nov. 4-17.
The Flames have 79 points and are tied with Minnesota for second place in the Northwest Division - two points behind leader Vancouver - and seventh in the Western Conference.
"It's a good thing to get on a roll at this time of the year. We needed to build some momentum and to start to feel better about our road game too," said Flames captain Jarome Iginla, who had a goal Saturday to give him seven in the last nine games.
Iginla leads Calgary with 31 goals and 73 points, but only nine of those goals and 23 of the points have come away from home. However, the All-Star right wing has 12 points in his last eight meetings with St. Louis.
Goaltender Miikka Kiprusoff has also dominated the Blues, with a 5-0-1 record and 1.48 goals-against average in his last six starts against them. He stopped 24 shots in a 3-0 home win over St. Louis on Nov. 14 - the last meeting between the teams.
Blues goaltender Curtis Sanford gave up one goal on four shots before exiting that game in the first period with a strained groin.
Sanford is likely to face the Flames again Tuesday as St. Louis opens a three-game homestand. He is 2-1-1 with a 2.40 GAA in four starts since replacing the injured Manny Legace, who underwent knee surgery on Feb. 27.
On Saturday, Sanford allowed a pair of goals in the third period and three more in the shootout of a 3-2 loss to the New York Rangers.
"We didn't make the saves that we needed to," said Sanford, who made 32 stops. "We may not have been intense enough. What can we say? We lost an extra point."
The Blues are looking to win their fifth straight home game for the first time since Nov. 4-25, 2003.