TIME: Saturday, 7 p.m. EST.
The Northeast Division-leading Senators have taken all six meetings from the last-place Leafs, outscoring them 36-12. Ottawa also has scored 11 power-play goals in 43 chances during the season series.
The Senators won by a combined 11-2 score in the two previous meetings in Toronto, including an 8-0 rout on Oct. 29.
They meet once more this season on April 15 at Air Canada Centre.
Ottawa, kicking off a five-game road trip, enters with three straight victories and trails Carolina by three points for the league lead.
The Senators got three assists from Andrej Meszaros and 30 saves from new starting goaltender Ray Emery in a 7-1 win over Washington on Thursday.
Emery, getting the start in place of the injured Dominik Hasek, won for the second straight night and 11th time in 16 starts this season.
Hasek suffered a strained adductor muscle in the Czech Republic's Olympic opener on Feb. 15 and will be sidelined indefinitely.
"I just want to play as well as I can each and every night and take it one step at a time," Emery said. "I haven't gotten ahead of myself. I just want to look forward to the next game and let Dom's situation and the rest take care of itself."
Emery got plenty of support from an offense that went 3-for-6 on the power play and scored two short-handed goals.
The Senators lead the NHL in goals with 234 and are 35-0-0 when scoring four goals in a game this season.
Leading scorer Daniel Alfredsson has 17 goals and 24 assists in 39 games versus the Leafs in his career, while Dany Heatley has 13 goals and 12 assists in 14 games, including eight goals and eight assists in the last seven meetings.
Toronto has lost four in a row and is 4-13-2 since having its season-high six-game winning streak snapped in a 1-0 loss to Calgary on Jan. 6.
The Leafs have dropped to 11th in the conference with 59 points, but trail eighth-place Montreal by just five points for the final playoff spot.
In a 6-2 loss to Buffalo on Friday, Alexei Ponikarovsky and Alexander Steen scored, but backup goalie Mikael Tellqvist allowed a pair of tallies in each period as the Sabres moved within four points of Ottawa in the division.
Toronto, outscored 19-9 during its losing skid, has allowed eight power-play goals over that span.
"When things aren't going good, you don't get the bounces," said leading scorer Bryan McCabe, who assisted on Steen's tally. "Things aren't going great right now, and we have to tough it out."
McCabe has six goals and 14 assists in 40 games against the Senators in his career.
STANDINGS: Senators - 83 points, 1st place, Northeast Division. Maple Leafs - 59 points, 5th place, 24 PB, Northeast Division.
TEAM LEADERS: Senators - Alfredsson and Heatley, 35 goals; Jason Spezza, 46 assists; Alfredsson, 77 points; Chris Neil, 155 PIM. Maple Leafs - Darcy Tucker, 24 goals; Jason Allison and Tomas Kaberle, 39 assists; Bryan McCabe, 54 points and 90 PIM.
SPECIAL TEAMS: Senators - Power play: 21 percent (74 for 352), 2nd (tied) in NHL. Penalty killing: 85.1 percent (302 for 355), 5th (tied). Maple Leafs - Power play: 19.9 percent (73 for 367), 4th. Penalty killing: 80.2 percent (299 for 373), 24th.
GOALTENDERS: Senators - Emery (11-4-1, 1 SO, 2.99 GAA); Billy Thompson (no record); Maple Leafs - Ed Belfour (21-21-3, 3.36); Tellqvist (6-6-2, 1, 3.01).
SEASON SERIES: Senators, 6-0.
LAST MEETING: Jan. 23; Senators, 4-3. At Ottawa, Alfredsson scored his 30th goal of the season and Hasek made 23 saves in the Senators' second home win over the Leafs in three days.
ROAD/HOME RECORDS: Senators - 16-8-4 on the road; Maple Leafs - 17-11-2 at home.