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St. Louis has won all four meetings against the Blue Jackets this season, with three of those victories coming by one goal. The Blues lead the all-time series 12-3-3-1, including 4-2-2-1 in Columbus.
In the last meeting at St. Louis on Thursday, the Blues scored three unanswered goals in the third period and rallied for a 5-3 victory.
"Do we feel snake bit against St. Louis? Yeah, big time," Columbus interim coach Gerard Gallant said following the loss. "We played them tough. We compete hard every night. We just seem to fall short."
The Blues have gone to overtime in their two games since that win, skating to a 2-2 tie Saturday against Minnesota and winning 2-1 at Florida on Monday on Pavol Demitra's goal 48 seconds into the extra period.
Demitra, who also scored St. Louis' first goal Monday, has four goals and three assists in the last five games after going pointless in his first three games back from a concussion.
"When he gets hot, he can get red hot," St. Louis coach Joel Quenneville said. "He is tough to contain because he smells that net very well. He's a guy who can really ignite our offense."
Blues left wing Keith Tkachuk assisted on both goals Monday, giving him seven assists in his last four games. Tkachuk leads the team with 19 goals, but has none in his past nine games.
Columbus has been a much improved team under Gallant, going 3-3-3 since replacing Doug MacLean on Jan. 1.
"I thought we should have won the game 7-3 or 7-4," Gallant said. "They had some luck tonight and we didn't."
Nash and rookie right wing Nikolai Zherdev have been the offensive catalysts for Columbus lately.
Nash has five goals and two assists in his last six games while Zherdev has three goals and two assists during a four-game point streak.