St. Louis went 7-0-2 from Dec. 2-20, but has since won just twice in nine games (2-5-2). The Blues' winless skid reached three with a 2-0 road loss to the Carolina Hurricanes on Tuesday.
St. Louis continued to struggle offensively. The Blues have scored only two goals over the last three games, and have been shut out twice in their last eight after not being blanked in their first 32 contests this season.
Blues coach Joel Quenneville said his club was outmatched in Tuesday's game.
"It looked like the strength on the puck and the energy levels were at two different levels, and they had a lot more of it," Quenneville said. "You could tell on the first goal, the puck's there, they beat us to the front of the net, it's in our net."
St. Louis could be without leading scorer Keith Tkachuk for Saturday's contest after he left toward the end of the second period Tuesday with a sore neck.
Nashville was without starting goalie Tomas Vokoun in its last contest on Thursday. Backup Chris Mason stopped 31 shots for his first NHL victory as the Predators beat the Colorado Avalanche 4-3 in overtime at the Gaylord Entertainment Center.
The Predators improved to 4-0-2-1 in their last seven home games.
Mason, selected in the waiver draft in October from the Florida Panthers, got the start because Vokoun had the flu.
"Chris was awesome," Nashville defenseman Jason York said. "He gave us a chance to win tonight."
If Vokoun is still ill, Mason will get the start Saturday, with Wade Flaherty serving as his backup.