Vancouver beat Edmonton 3-0 on Oct. 11 to improve to 5-0-1 against the Oilers since a 2-0 home loss on March 24, 2002.
The Canucks will be trying to get back on track after their five-game unbeaten streak ended with a 3-1 road loss to the Dallas Stars on Wednesday. It was just Vancouver's second defeat in its last 10 games (5-2-3).
Dallas scored twice during a three-minute stretch of the third period to beat the weary Canucks, who were playing their third game in four days.
The Canucks have scored the second-most goals in the Western Conference, but they have scored two goals or fewer in six of their last seven games.
"We're not doing the little things," Canucks defenseman Sami Salo said. "We're not being tough in front of the net. We're not keeping it simple. We've got a lot of talent here, we should be playing better."
Edmonton is winless in its last two after skating to a 1-1 tie with the Minnesota Wild at home on Thursday. The Oilers have won just twice in their last 13 overall (2-7-4) to fall into last place in the Northwest.
"If he gets the opportunity -- like he did -- he can put it in the back of the net," Oilers coach Craig MacTavish said of Isbister, who has four goals in 22 games. "We don't have a lot of guys who can make that shot. He put himself in a good position and Ryan made a great pass."