Columbus has lost each of its last five road games, and is a dismal 0-10-1-1 away from home this season. The Blue Jackets are winless in 14 road games dating to last season (0-12-1-1).
That streak continued on Saturday night as the Blue Jackets remained the only NHL team without a road win this season, allowing three one-goal leads to slip away in a 5-3 loss to the Pittsburgh Penguins.
Columbus, in the midst of playing 11 of 16 games away from home, is also winless in five straight overall.
"It's tough, because every time we go on the road we think we're going to get the monkey off our backs and we have disappointing efforts," Blue Jackets forward Rick Nash said. "When you don't come ready to play, it's disappointing."
Columbus now faces the daunting task of beating St. Louis on its home ice. The Blues are 10-2-1 at the Savvis Center this season, and are 6-1-1 all-time at home against the Blue Jackets.
St. Louis has won four in a row, and is unbeaten in six straight overall after beating the Los Angeles Kings 2-1 at home on Saturday.
"I'd love to have a blowout, but it's not in the cards right now," Blues center Doug Weight said. "We have to be great defensively. We might win three in a row 6-1 or 6-3 or 6-4 if we just let loose. But we're not going to be 18-6 if we're playing that type of game."
Osgood earned his 289th career victory, which ranks sixth among active goaltenders.
"I think we'd like to score a little more and we've been having some trouble putting teams away after getting leads but we held the fort," Osgood said. "Hey, it's a tough league. I mean every team is good and there are no easy nights."